U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Other

Class (Stereo):
CHEMICAL (EPIMERIC)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Nystatin A1 is the one of the first member of important class of a macrocyclic polyene and poly-ol antibiotics isolated from Streptomyces noursei in 1950. Nystatin A1 binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage, acidification, and death of the fungus. Nystatin A1 is major component of Nystatin an important antifungal antibiotic, which for over half a century has been broadly used in medicine for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

mixture
Status:
First approved in 1954
Source:
Mycostatin by Squibb
Source URL:

Class:
MIXTURE